ea0041oc3.2 | Diabetes prediction & complications | ECE2016
Timper Katharina
, Dalmas Elise
, Dror Erez
, Rutti Sabine
, Thienel Constanze
, Sauter Nadine S.
, Bouzakri Karim
, Bedat Benoit
, Pattou Francois
, Kerr-Conte Julie
, Boni-Schnetzler Marianne
, Donath Marc Y.
Introduction: Glucose-dependent insulinotropic peptide (GIP) induces the cytokine interleukin (IL)-6 in adipocytes. IL-6 enhances insulin secretion from β-cells via L- and α-cell-derived GLP-1.Therefore we hypothesized that GIP regulates Glucagon-like peptide (GLP)-1 as well as glucose control via IL-6.Methods/Design: Basic research study on isolated human and mouse pancreatic islets and FACS-sorted human α-and β-cells that were treat...